Molecular mechanisms of memory reconsolidation

Nat Rev Neurosci. 2007 Apr;8(4):262-75. doi: 10.1038/nrn2090.


Memory reconsolidation has been argued to be a distinct process that serves to maintain, strengthen or modify memories. Specifically, the retrieval of a previously consolidated memory has been hypothesized to induce an additional activity-dependent labile period during which the memory can be modified. Understanding the molecular mechanisms of reconsolidation could provide crucial insights into the dynamic aspects of normal mnemonic function and psychiatric disorders that are characterized by exceptionally strong and salient emotional memories.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Emotions / physiology
  • Humans
  • Memory / physiology*
  • Mental Disorders / physiopathology
  • Mental Disorders / psychology
  • Neuronal Plasticity / physiology
  • Stress Disorders, Post-Traumatic / physiopathology
  • Stress Disorders, Post-Traumatic / psychology