Association of serum fetuin-A levels with mortality in dialysis patients

Kidney Int. 2007 Jul;72(2):202-7. doi: 10.1038/ Epub 2007 Mar 7.


Calcifying atherosclerosis is an active process, which is controlled by calcification inhibitors and inducers. Fetuin-A, an acute phase glycoprotein, is one of the more powerful circulating inhibitors of hydroxyapatite formation. A prospective multicenter cohort study was initiated to include both hemodialysis (HD) and peritoneal dialysis (PD) patients in an evaluation of the association of serum fetuin-A levels with both cardiovascular (CV) and non-CV mortality. An increase in the serum fetuin-A concentration of 0.1 g/l was associated with a significant reduction in all-cause mortality of 13%. There was a significant 17% reduction in non-CV mortality and a near significant reduction in CV mortality. This association of fetuin-A and mortality rates was comparable in both HD and PD patients even when corrected for factors, including but not limited to age, gender, primary kidney disease, C-reactive protein levels, and nutritional status. We conclude that serum fetuin-A concentrations may be a general predictor of mortality in dialysis patients.

Publication types

  • Multicenter Study

MeSH terms

  • Aged
  • Cardiovascular Diseases
  • Cohort Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Mortality
  • Peritoneal Dialysis / mortality
  • Predictive Value of Tests*
  • Prospective Studies
  • Renal Dialysis / mortality*
  • Survival Analysis
  • alpha-Fetoproteins / analysis*


  • alpha-Fetoproteins