Increased BRCA1 protein in mammary tumours of rats fed marine omega-3 fatty acids

Oncol Rep. 2007 Apr;17(4):713-9.

Abstract

Any factor affecting BRCA gene regulation may be of interest in the prevention of breast tumourigenesis. We studied the influence of dietary docosahexaenoic acid (DHA), a major omega-3 fatty acid present in marine products, on rat autochthonous mammary tumourigenesis. DHA-supplementation significantly reduced the incidence of tumours (30%, P=0.007) and led to a 60% increase (P=0.02) in BRCA1 protein level. Since DHA influences the product of a major tumour suppressor gene, this finding may contribute to the observation that high-fish consumption reduces the risk of breast cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • BRCA1 Protein / analysis
  • BRCA1 Protein / genetics
  • BRCA1 Protein / metabolism*
  • Dietary Fats, Unsaturated / administration & dosage*
  • Docosahexaenoic Acids / administration & dosage*
  • Fatty Acids, Omega-3 / administration & dosage*
  • Female
  • Mammary Neoplasms, Animal / chemistry
  • Mammary Neoplasms, Animal / metabolism*
  • Mammary Neoplasms, Animal / prevention & control*
  • RNA, Messenger / analysis
  • RNA, Messenger / metabolism
  • Rats
  • Rats, Sprague-Dawley
  • Up-Regulation

Substances

  • BRCA1 Protein
  • Dietary Fats, Unsaturated
  • Fatty Acids, Omega-3
  • RNA, Messenger
  • Docosahexaenoic Acids