The impact of the depth of embryo replacement on IVF outcome

J Assist Reprod Genet. 2007 May;24(5):189-93. doi: 10.1007/s10815-007-9110-4. Epub 2007 Mar 8.


Purpose: To evaluate the effect of the depth of embryo transfer replacement on clinical pregnancy rate.

Methods: Data from a total of 104 consecutive embryo transfers performed on 104 women aged 26-37 years were prospectively collected for this study. All patients underwent a standard down regulation protocol for ovarian stimulation. Oocytes retrieval were performed at 36 h after hCG administration. Embryo transfer took place at 48 h after insemination. The patients were matched in two groups according to the distance between the tip of the catheter and the uterine fundus at transfer (group A > 10 < 15 mm and group B < or = 10 mm). The same method of loading embryos into the embryo transfer catheter was used.

Results: Clinical pregnancy rates varied significantly (p < or = 0.05) between the two groups: 27.7% in group A and 14% in group B. The number and quality of embryos transferred did not differ between the groups.

Conclusions: The results suggest that the depth of embryo replacement may be an important variable in embryo transfer technique.

MeSH terms

  • Adult
  • Embryo, Mammalian / physiology*
  • Estradiol / blood
  • Female
  • Fertilization in Vitro / methods*
  • Follicle Stimulating Hormone / blood
  • Humans
  • Infertility, Female / classification
  • Pregnancy
  • Pregnancy Outcome*


  • Estradiol
  • Follicle Stimulating Hormone