Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 22 (6), 757-65

Effect of Medical and Surgical Interventions on Health-Related Quality of Life in Parkinson's Disease

Affiliations
Review

Effect of Medical and Surgical Interventions on Health-Related Quality of Life in Parkinson's Disease

Pablo Martinez-Martin et al. Mov Disord.

Abstract

Motor-related parameters are the standard outcome parameters for treatment interventions. Nonetheless, subjective appraisals about the consequences of treatment on health-related quality of life (HRQoL) are meanwhile established and may uncover important aspects of interventions. We have reviewed the literature with a defined search strategy and collected 61 clinical trials, which have used HRQoL as a planned outcome parameter. The articles were rated similarly as for the Task Force report of the Movement Disorder Society on interventions for Parkinson's disease (PD), but the relevant outcome parameter was HRQoL. We found that unilateral pallidotomy, deep brain stimulation of the subthalamic nucleus, and rasagiline are efficacious to improve the HRQoL of PD patients. For many other interventions, the efficacy to improve HRQoL in the PD setting cannot be considered to be proven so far. HRQoL should be part of future trial designs and more research is necessary to understand the determinants of QoL in PD.

Similar articles

See all similar articles

Cited by 16 articles

See all "Cited by" articles

LinkOut - more resources

Feedback