Nutritional interventions in critical illness

Proc Nutr Soc. 2007 Feb;66(1):16-24. doi: 10.1017/S0029665107005253.


The metabolism of critical illness is characterised by a combination of starvation and stress. There is increased production of cortisol, catecholamines, glucagon and growth hormone and increased insulin-like growth factor-binding protein-1. Phagocytic, epithelial and endothelial cells elaborate reactive oxygen and nitrogen species, chemokines, pro-inflammatory cytokines and lipid mediators, and antioxidant depletion ensues. There is hyperglycaemia, hyperinsulinaemia, hyperlactataemia, increased gluconeogenesis and decreased glycogen production. Insulin resistance, particularly in relation to the liver, is marked. The purpose of nutritional support is primarily to save life and secondarily to speed recovery by reducing neuropathy and maintaining muscle mass and function. There is debate about the optimal timing of nutritional support for the patient in the intensive care unit. It is generally agreed that the enteral route is preferable if possible, but the dangers of the parenteral route, a route of feeding that remains important in the context of critical illness, may have been over-emphasised. Control of hyperglycaemia is beneficial, and avoidance of overfeeding is emphasised. Growth hormone is harmful. The refeeding syndrome needs to be considered, although it has been little studied in the context of critical illness. Achieving energy balance may not be necessary in the early stages of critical illness, particularly in patients who are overweight or obese. Protein turnover is increased and N balance is often negative in the face of normal nutrient intake; optimal N intakes are the subject of some debate. Supplementation of particular amino acids able to support or regulate the immune response, such as glutamine, may have a role not only for their potential metabolic effect but also for their potential antioxidant role. Doubt remains in relation to arginine supplementation. High-dose mineral and vitamin antioxidant therapy may have a place.

Publication types

  • Review

MeSH terms

  • Amino Acids / metabolism*
  • Antioxidants / metabolism
  • Antioxidants / therapeutic use
  • Critical Care / methods*
  • Critical Care / standards
  • Critical Illness / therapy*
  • Energy Metabolism / physiology*
  • Glutamine / metabolism
  • Glutamine / therapeutic use
  • Humans
  • Nutritional Requirements
  • Nutritional Support / methods*
  • Oxidative Stress / drug effects
  • Time Factors


  • Amino Acids
  • Antioxidants
  • Glutamine