Vascular Endothelial Growth Factor Family of Ligands and Receptors: Review

Blood Cells Mol Dis. May-Jun 2007;38(3):258-68. doi: 10.1016/j.bcmd.2006.12.003. Epub 2007 Mar 6.

Abstract

VEGF signaling often represents a critical rate-limiting step in physiological angiogenesis. The VEGF family comprises seven secreted glycoproteins that are designated VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, placental growth factor (PlGF) and VEGF-F. The VEGF family members bind their cognate receptors. The receptors identified so far are designated VEGFR-1, VEGFR-2, VEGFR-3 and the neuropilins (NP-1 and NP-2). We review in this article the biology of the VEGF ligands and the receptors.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Ligands
  • Neovascularization, Pathologic*
  • Neovascularization, Physiologic*
  • Receptors, Vascular Endothelial Growth Factor*
  • Vascular Endothelial Growth Factors*

Substances

  • Ligands
  • Vascular Endothelial Growth Factors
  • Receptors, Vascular Endothelial Growth Factor