Osteoarticular complications of brucellosis in Hamedan, an endemic area in the west of Iran

Int J Infect Dis. 2007 Nov;11(6):496-500. doi: 10.1016/j.ijid.2007.01.008. Epub 2007 Mar 6.


Objective: To determine the frequency and clinical characteristics of osteoarticular complications of brucellosis in an endemic region in Iran.

Methods: In a prospective study we evaluated 245 patients with brucellosis diagnosed between January 2004 and December 2005. Patients included were those older than 8 years of age and who had clinical features suggestive of brucellosis and specific antibodies at significant titers, and/or positive blood or body fluid culture for Brucella species. A bone scan was performed in those with a clinical suspicion of osteoarticular involvement.

Results: Seventy patients (28.6%) had osteoarticular complications. Sacroiliitis was the most common complication (75.7%), followed by spondylitis (21.4%) and peripheral arthritis (8.6%). Spondylitis was the most common osteoarticular complication in the elderly. Relapses occurred in five (2%) patients, three of them with spondylitis.

Conclusions: Osteoarticular disease is the most common complication of brucellosis in Western Iran. Sacroiliitis is the most common form of osteoarticular complication. With the use of a proper treatment regimen, the prospect for recovery is good.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Arthritis, Infectious / epidemiology
  • Arthritis, Infectious / etiology*
  • Brucellosis / complications*
  • Brucellosis / epidemiology
  • Child
  • Endemic Diseases*
  • Female
  • Humans
  • Iran / epidemiology
  • Male
  • Middle Aged