Clustering of IgA-producing immunocytes related to HLA-DR-positive ducts in normal and inflamed salivary glands

Scand J Immunol. 1992 Jan;35(1):43-51. doi: 10.1111/j.1365-3083.1992.tb02832.x.


Ig-producing immunocytes and epithelial expression of secretory component (SC) and HLA-DR were evaluated by two-colour immunofluorescence staining in 10 normal and 20 inflamed salivary glands; the latter included specimens from 10 patients with obstructive sialadenitis and 10 with Sjögren's syndrome (SS). Epithelium adjacent to T-cell infiltrates showed extensive co-expression of SC and HLA-DR, suggesting that leucocyte-derived cytokines were responsible for this concurrent up-regulation. Clusters (greater than 2 positive cells) of IgA-producing cells were spatially related to DR-positive ducts. The possibility is discussed that DR-expressing epithelium contributes to local terminal differentiation of IgA-producing plasma cells. A cytokine-mediated up-regulation of SC that simultaneously increases the transport capacity for polymeric IgA would constitute an efficient enhancement of secretory immunity in diseased glandular tissue.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Antibody-Producing Cells / cytology*
  • Female
  • HLA-DR Antigens / analysis*
  • Humans
  • Immunoglobulin A / immunology*
  • Male
  • Middle Aged
  • Salivary Glands / cytology*
  • Salivary Glands / immunology*
  • Sialadenitis / immunology*
  • Sjogren's Syndrome / immunology


  • HLA-DR Antigens
  • Immunoglobulin A