A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols

Chem Commun (Camb). 2006 Dec 14:(46):4835-7. doi: 10.1039/b612197g.

Abstract

A general flow process for the multi-step assembly of peptides has been developed and this procedure has been used to successfully construct a series of Boc, Cbz and Fmoc N-protected dipeptides in excellent yields and purities, including an extension of the method to enable the preparation of a tripeptide derivative.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / chemistry
  • Indicators and Reagents
  • Microfluidic Analytical Techniques / instrumentation*
  • Microfluidic Analytical Techniques / methods*
  • Peptides / chemical synthesis*
  • Peptides / chemistry*

Substances

  • Amino Acids
  • Indicators and Reagents
  • Peptides