Abstract
[structure: see text]. The aldol reaction of methyl ketones and alpha,beta-unsaturated trifluoromethyl ketones occurred under mild conditions with the combination of proline-derived N-sulfonylamide and trifluoroacetic acid as the catalyst to give the corresponding unsaturated alpha-trifluoromethyl tertiary alcohols in high yields with good enatioselectivities.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetone / chemistry
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Aldehydes / chemistry*
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Catalysis
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Hydrocarbons, Fluorinated / chemical synthesis
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Hydrocarbons, Fluorinated / chemistry*
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Ketones / chemistry*
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Molecular Structure
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Proline / chemistry
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Stereoisomerism
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Sulfur Compounds / chemistry
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Trifluoroacetic Acid / chemistry
Substances
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Aldehydes
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Hydrocarbons, Fluorinated
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Ketones
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Sulfur Compounds
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Acetone
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3-hydroxybutanal
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Proline
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Trifluoroacetic Acid