GATA-3 - not just for Th2 cells anymore

Cell Mol Immunol. 2007 Feb;4(1):15-29.


GATA-3 was first cloned as a T cell specific transcription factor in 1991 and its importance in the transcriptional control of T helper type 2 cell (Th2) differentiation was established in the mid to late 90's. A role for GATA-3 during thymic development has long implied by its continuous and regulated expression through out T lineage development, but the absolute requirement for GATA-3 during early T lymphoid commitment/survival previously precluded definitive answers to this question. Several technical breakthroughs have fueled fruitful investigation in recent years and uncovered unexpected and critical roles for GATA-3 in CD4 thymocyte survival, invariant natural killer T cell generation and function, and also in beta selection. Not only does GATA-3 participate in nearly every stage of T cell development from common lymphoid progenitor to Th2, conditional knockout studies have indicated that the influence of GATA-3 also extends beyond the immune system.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation* / genetics
  • GATA3 Transcription Factor / genetics
  • GATA3 Transcription Factor / metabolism
  • GATA3 Transcription Factor / physiology*
  • Humans
  • Th2 Cells / cytology
  • Th2 Cells / immunology*
  • Thymus Gland / cytology
  • Thymus Gland / immunology*


  • GATA3 Transcription Factor