Fundamental differences in samples, procedures, nature of results, automation, productivity, staffing levels, and background decision making along work flow and turnaround times characterize histology as a unique area within the medical laboratory. For histology laboratories to function successfully, individual and collective training, well-defined goals, and implemented accountabilities with effective supervision are required. The pathologist, as immediate client of the histology laboratory, has to be involved in the whole operation to assure optimal patient care.