Energy drinks contain a mixture of compounds, of which caffeine, guarana, and herbal supplements such as ginkgo and ginseng are major components. Survey of popular literature reveals anecdotal observations of adverse events associated with consumption of energy drinks. However, there are no reported cases in the published literature. We report a series of four patients who had discrete seizures on multiple occasions, following heavy consumption of energy drinks. Once the patients were abstinent from the energy drinks, no recurrent seizures were reported. We propose that the large consumption of energy drinks rich in caffeine, taurine, and guarana seed extract could have provoked these seizures.