c-Kit--a hematopoietic cell essential receptor tyrosine kinase

Int J Biochem Cell Biol. 2007;39(11):1995-8. doi: 10.1016/j.biocel.2006.12.005. Epub 2007 Jan 20.

Abstract

The receptor tyrosine kinase c-Kit is expressed in hematopoietic stem and progenitor cells and in several non-hematopoietic tissues. In the hematopoietic system, c-Kit is critical for proliferation, survival and differentiation. During recent years exploration of the signalling pathways downstream of this receptor has yielded significant new insights in the field. In this review, we will summarise the c-Kit background, structure, downstream signalling and medical significance with particular focus on its role in hematopoietic progenitor cells and mast cells.

Publication types

  • Review

MeSH terms

  • Animals
  • Hematopoietic System / cytology*
  • Hematopoietic System / enzymology*
  • Humans
  • Proto-Oncogene Proteins c-kit / chemistry
  • Proto-Oncogene Proteins c-kit / metabolism*
  • Signal Transduction

Substances

  • Proto-Oncogene Proteins c-kit