The sunny side of p53

Cell. 2007 Mar 9;128(5):826-8. doi: 10.1016/j.cell.2007.02.027.

Abstract

Skin, the largest organ of our body, is often plagued by cancer because of exposure to ultraviolet radiation from the sun. A report by Cui et al. (2007) in this issue of Cell explains how the tumor suppressor p53 protects the skin by stimulating the suntan response.

Publication types

  • Comment
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • DNA Damage
  • Genes, p53
  • Humans
  • Keratinocytes / metabolism
  • Keratinocytes / radiation effects
  • Melanins / biosynthesis
  • Melanocytes / metabolism
  • Melanocytes / radiation effects
  • Mice
  • Pro-Opiomelanocortin / genetics
  • Pro-Opiomelanocortin / metabolism
  • Skin / metabolism*
  • Skin / radiation effects*
  • Skin Neoplasms / genetics
  • Skin Pigmentation
  • Tumor Suppressor Protein p53 / metabolism*
  • Ultraviolet Rays / adverse effects*
  • alpha-MSH / genetics

Substances

  • Melanins
  • Tumor Suppressor Protein p53
  • alpha-MSH
  • Pro-Opiomelanocortin