Abstract
Skin, the largest organ of our body, is often plagued by cancer because of exposure to ultraviolet radiation from the sun. A report by Cui et al. (2007) in this issue of Cell explains how the tumor suppressor p53 protects the skin by stimulating the suntan response.
Publication types
-
Comment
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
DNA Damage
-
Genes, p53
-
Humans
-
Keratinocytes / metabolism
-
Keratinocytes / radiation effects
-
Melanins / biosynthesis
-
Melanocytes / metabolism
-
Melanocytes / radiation effects
-
Mice
-
Pro-Opiomelanocortin / genetics
-
Pro-Opiomelanocortin / metabolism
-
Skin / metabolism*
-
Skin / radiation effects*
-
Skin Neoplasms / genetics
-
Skin Pigmentation
-
Tumor Suppressor Protein p53 / metabolism*
-
Ultraviolet Rays / adverse effects*
-
alpha-MSH / genetics
Substances
-
Melanins
-
Tumor Suppressor Protein p53
-
alpha-MSH
-
Pro-Opiomelanocortin