Further evidence for BRCA1 communication with the inactive X chromosome

Cell. 2007 Mar 9;128(5):991-1002. doi: 10.1016/j.cell.2007.02.025.


BRCA1, a breast and ovarian cancer-suppressor gene, exerts tumor-suppressing functions that appear to be associated, at least in part, with its DNA repair, checkpoint, and mitotic regulatory activities. Earlier work from our laboratory also suggested an ability of BRCA1 to communicate with the inactive X chromosome (Xi) in female somatic cells (Ganesan et al., 2002). Xiao et al. (2007) (this issue of Cell) have challenged this conclusion. Here we discuss recently published data from our laboratory and others and present new results that, together, provide further support for a role of BRCA1 in the regulation of XIST concentration on Xi in somatic cells.

Publication types

  • Comment
  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • BRCA1 Protein / genetics
  • BRCA1 Protein / metabolism*
  • Cell Line, Tumor
  • Embryo, Mammalian / cytology
  • Female
  • Fibroblasts
  • Genes, BRCA1
  • Genes, BRCA2
  • Mammary Neoplasms, Experimental / genetics
  • Mammary Neoplasms, Experimental / metabolism
  • Mice
  • Mutation
  • RNA Interference
  • RNA, Long Noncoding
  • RNA, Untranslated / metabolism*
  • X Chromosome / metabolism*
  • X Chromosome Inactivation*


  • BRCA1 Protein
  • RNA, Long Noncoding
  • RNA, Untranslated
  • XIST non-coding RNA