Antiproliferative and antioxidant activities of a tricin acylated glycoside from sugarcane (Saccharum officinarum) juice

Phytochemistry. 2007 Apr;68(8):1165-71. doi: 10.1016/j.phytochem.2007.01.015. Epub 2007 Mar 12.

Abstract

From sugarcane juice, a flavone, identified by spectroscopic methods as tricin-7-O-beta-(6''-methoxycinnamic)-glucoside, was isolated, in addition to orientin. The tricin derivative was shown to have antioxidant activity higher than Trolox by means of the DPPH assay and lower by the beta-carotene/linoleic acid system. It showed in vitro antiproliferative activity against several human cancer cell lines, with higher selectivity toward cells of the breast resistant NIC/ADR line.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / pharmacology*
  • Antioxidants / chemistry
  • Antioxidants / isolation & purification
  • Antioxidants / pharmacology*
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Chromans / pharmacology
  • Flavonoids / chemistry
  • Flavonoids / isolation & purification
  • Flavonoids / pharmacology
  • Glucosides / chemistry
  • Glucosides / isolation & purification
  • Glucosides / pharmacology*
  • Humans
  • Saccharum / chemistry*

Substances

  • Antineoplastic Agents
  • Antioxidants
  • Chromans
  • Flavonoids
  • Glucosides
  • tricin-7-O-beta-(6''-methoxycinnamic)glucoside
  • orientin
  • 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid