Src kinase signaling in leukaemia

Int J Biochem Cell Biol. 2007;39(7-8):1483-8. doi: 10.1016/j.biocel.2007.01.027. Epub 2007 Feb 9.


Role of Src kinases in acute lymphoblastic leukaemia has been recently demonstrated in leukaemia mouse model. Retained activation of Src kinases by the BCR-ABL oncoprotein in leukaemic cells following inhibition of BCR-ABL kinase activity by imatinib indicates that Src activation by BCR-ABL is independent of BCR-ABL kinase activity and provides an explanation for reduced effectiveness of the BCR-ABL kinase activity inhibitors in Philadelphia chromosome-positive acute lymphoblastic leukaemia. Simultaneous inhibition of kinase activity of both BCR-ABL and Src kinases results in long-term survival of mice with acute lymphoblastic leukaemia. Leukaemic stem cells exist in acute lymphoblastic leukaemia, and complete eradication of this group of cells would provide a curative therapy for this disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use
  • Benzamides
  • Cell Survival / drug effects
  • Enzyme Activation
  • Gene Expression Regulation, Leukemic
  • Genes, abl / physiology*
  • Humans
  • Imatinib Mesylate
  • Mice
  • Neoplastic Stem Cells / cytology*
  • Piperazines / pharmacology
  • Piperazines / therapeutic use*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / enzymology*
  • Pyrimidines / pharmacology
  • Pyrimidines / therapeutic use*
  • Signal Transduction*
  • src-Family Kinases / antagonists & inhibitors
  • src-Family Kinases / physiology*


  • Antineoplastic Agents
  • Benzamides
  • Piperazines
  • Pyrimidines
  • Imatinib Mesylate
  • src-Family Kinases