Evaluation of insulin-like growth factor-1 in a mouse model of long-term abdominal radiation toxicity

Anticancer Res. 2007 Jan-Feb;27(1A):183-7.


The purpose of these experiments was to test whether a brief course of insulin-like growth factor-1 (IGF-1) injection (escalating doses) concomitant to irradiation ameliorates radiation-induced kidney dysfunction and lethal bowel toxicity in a mouse model of unilateral high-dose irradiation of the kidney and adjacent bowel. The kidney function was assessed by means of repeated 99mTc-dimercaptosuccinate scans (every six weeks) during a maximum follow-up of 49 weeks. The experiments with single fractions of 12 Gy and 15 Gy revealed only minor differences in the severity of kidney dysfunction and no reduction in lethal bowel toxicity from IGF-1 treatment In the absence of any significant radioprotective effect, other strategies of response modification need to be developed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Dose-Response Relationship, Radiation
  • Female
  • Insulin-Like Growth Factor I / pharmacology*
  • Intestinal Diseases / etiology
  • Intestinal Diseases / prevention & control*
  • Intestines / radiation effects
  • Kidney / diagnostic imaging
  • Kidney / radiation effects
  • Kidney Diseases / diagnostic imaging
  • Kidney Diseases / etiology
  • Kidney Diseases / prevention & control*
  • Mice
  • Mice, Inbred C3H
  • Radiation Injuries, Experimental / diagnostic imaging
  • Radiation Injuries, Experimental / prevention & control*
  • Radiation-Protective Agents / pharmacology*
  • Radionuclide Imaging
  • Radiopharmaceuticals
  • Technetium Tc 99m Dimercaptosuccinic Acid


  • Radiation-Protective Agents
  • Radiopharmaceuticals
  • Technetium Tc 99m Dimercaptosuccinic Acid
  • Insulin-Like Growth Factor I