Acute life threatening event (ALTE) in an infant with human coronavirus HCoV-229E infection

Pediatr Pulmonol. 2007 Apr;42(4):393-6. doi: 10.1002/ppul.20595.


In this short report we discuss the temporal association between an acute life threatening event (ALTE) and a RT-PCR confirmed coronavirus HCoV-229E infection in a 4 months old otherwise healthy infant. More detailed microbiological investigations of affected children even without apparent signs of a respiratory tract infection may help to clarify the etiology in some patients and extend our understanding of the pathogenesis. PCR-based techniques should be utilized to increase the sensitivity of detection for old and new respiratory viral pathogens in comparable cases.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apnea / etiology*
  • Bradycardia / etiology*
  • Coronavirus 229E, Human / genetics
  • Coronavirus 229E, Human / isolation & purification
  • Coronavirus Infections / diagnosis*
  • Critical Illness*
  • DNA, Viral / isolation & purification
  • Female
  • Humans
  • Infant
  • Reverse Transcriptase Polymerase Chain Reaction


  • DNA, Viral