Measurement of bile acid half-life using [75Se]HCAT in health and intestinal diseases. Comparison with [75Se]HCAT abdominal retention methods

Dig Dis Sci. 1992 Feb;37(2):225-32. doi: 10.1007/BF01308176.


The diagnostic values in detecting terminal ileum dysfunction using [75Se]HCAT have been assessed for two different scintigraphic techniques in 58 subjects. The measurement of [75Se]HCAT T1/2 in the enterohepatic circulation by daily gallbladder scintigraphy showed 78% sensitivity, 96% specificity, 96% positive predictive value, and 78% negative predictive value at the optimal cutoff level of 2.0 days; lower--but not significantly different--figures were observed for [75Se]HCAT total abdominal retention four and seven days after isotope administration, at the optimal cutoff levels of 40% and 22%, respectively. [75Se]HCAT T1/2 was then evaluated in 60 patients with various intestinal diseases. Sixty-nine percent (9/13) of patients with diarrhea of obscure origin showed abnormal [75Se]HCAT T1/2. Bile acid malabsorption using [75Se]HCAT can be investigated by the noninvasive measurement of its enterohepatic T1/2 and may play a pathogenetic role in patients with diarrhea of obscure origin.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Cholecystectomy
  • Colitis / metabolism
  • Colitis, Ulcerative / metabolism*
  • Crohn Disease / metabolism*
  • Diarrhea / metabolism
  • Female
  • Half-Life
  • Humans
  • Ileitis / metabolism
  • Malabsorption Syndromes / metabolism
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Selenium Radioisotopes / pharmacokinetics*
  • Sensitivity and Specificity
  • Taurocholic Acid / pharmacokinetics*


  • Selenium Radioisotopes
  • Taurocholic Acid