A 64-year-old woman was admitted to our surgical emergency department suffering from epigastric pain and fever persisting for a period of 5 weeks, and, upon admission, she presented with massively elevated C-reactive protein. Computed tomography (CT) demonstrated a giant hemangioma of the liver with an intralesional central mass, which was documented by diameter progression of the central mass on follow-up CT. After liver resection, the diagnosis was an abscess in a giant liver hemangioma.