Pregnancy on intensified hemodialysis: fetal surveillance and perinatal outcome

Fetal Diagn Ther. 2007;22(4):289-93. doi: 10.1159/000100793. Epub 2007 Mar 15.


Objectives: To evaluate the effect of intensive fetal surveillance via Doppler ultrasound and fetal non-stress test on the perinatal outcome of pregnant women undergoing an intensified hemofiltration scheme.

Methods: Five consecutive pregnancies of women undergoing intensified hemodialysis were analyzed due to the following parameters: maternal background, hemodialysis schedule during pregnancy, blood pressure, occurrence of fetal complications, occurrence of obstetric complications, gestational week at delivery, mode of delivery, and newborn outcome and follow-up.

Results: All pregnancies resulted in a live birth, mean gestational age was 32 weeks. Intrauterine growth restriction occurred in 4 fetuses, pathological umbilical artery flow velocity waveforms in 2. The mean birth weight was 1,764 g (range 1,274-2,465 g). Cesarean section was performed in 3 patients because of fetal distress. None of the patients developed severe complications like pre-eclampsia.

Conclusions: Although intensified dialysis enables the maintenance of stable uteroplacental and fetal perfusion, intensive fetal monitoring is mandatory to reduce perinatal morbidity and mortality in pregnant women on maintenance dialysis.

MeSH terms

  • Adult
  • Birth Weight
  • Blood Flow Velocity
  • Cardiotocography*
  • Child, Preschool
  • Female
  • Fetal Distress / etiology
  • Fetal Growth Retardation / etiology
  • Follow-Up Studies
  • Gestational Age
  • Humans
  • Infant
  • Kidney Failure, Chronic / physiopathology
  • Kidney Failure, Chronic / therapy*
  • Laser-Doppler Flowmetry*
  • Live Birth
  • Placental Circulation
  • Polyhydramnios / etiology
  • Pregnancy
  • Pregnancy Complications / physiopathology
  • Pregnancy Complications / therapy*
  • Prenatal Care / methods*
  • Renal Dialysis / adverse effects*
  • Retrospective Studies
  • Time Factors
  • Ultrasonography, Prenatal*