Probiotic capsules do not lower plasma lipids in young women and men

Eur J Clin Nutr. 2008 Feb;62(2):232-7. doi: 10.1038/sj.ejcn.1602719. Epub 2007 Mar 14.


Objective: To investigate the effect of probiotic capsules on plasma lipids.

Design: A randomized, single-blinded, placebo-controlled, parallel-arm trial.

Subjects: Fifty-five normocholesterolemic subjects ages 18-36 (33 premenopausal women and 22 men).

Intervention: Each subject consumed either three probiotic capsules each containing a total of 10(9) colony-forming units Lactobacillus acidophilus and Bifidobacterium longum and 10-15 mg fructo-oligosaccharide or three placebo capsules daily for 2 months (men) or two menstrual cycles (women). Plasma lipids were measured before and following the intervention (during the early follicular phase for women).

Results: Plasma concentrations of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglyceride were not altered by consumption of probiotic or placebo capsules and were not different between treatment groups following the intervention.

Conclusions: These results do not support a beneficial effect of Lactobacillus acidophilus strain DDS-1 and Bifidobacterium longum strain UABL-14 on plasma lipids in normocholesterolemic young women and men.

Sponsorship: Supported by the Minnesota Agricultural Experiment Station and UAS Laboratories.

Publication types

  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Bifidobacterium / physiology*
  • Cholesterol / blood
  • Cholesterol, HDL / blood
  • Cholesterol, LDL / blood
  • Colony Count, Microbial
  • Female
  • Humans
  • Lactobacillus acidophilus / physiology*
  • Lipid Metabolism / drug effects
  • Lipids / blood*
  • Male
  • Oligosaccharides / pharmacology*
  • Probiotics*
  • Single-Blind Method
  • Triglycerides / blood


  • Cholesterol, HDL
  • Cholesterol, LDL
  • Lipids
  • Oligosaccharides
  • Triglycerides
  • fructooligosaccharide
  • Cholesterol