Prevention of antibiotic-associated diarrhoea by a fermented probiotic milk drink

Eur J Clin Nutr. 2008 Feb;62(2):299-301. doi: 10.1038/sj.ejcn.1602718. Epub 2007 Mar 14.


Objective: To study the preventive effect of a milk drink fermented with multistrain probiotics on antibiotic associated diarrhoea (AAD).

Design: Double-blind placebo controlled study.

Setting: University Hospital of North Norway.

Subjects and methods: Of 853 patients treated with antibiotics, 87 met the inclusion criteria, and were randomized to ingestion of a fermented milk drink containing LGG, La-5 and Bb-12 (n=46) or placebo with heat-killed bacteria (n=41), during a period of 14 days. A diary was recorded, and stool samples were collected for microbiological analyses.

Results: Sixty-three patients completed the study according to the protocol; two patients (5.9%) in the treatment group and eight (27.6%) in the placebo group developed AAD (P=0.035). The relative risk of developing AAD was 0.21 (95% confidence interval: 0.05-0.93) when given probiotic milk drink.

Conclusion: A fermented multistrain probiotic milk drink may prevent four of five cases of AAD in adult hospitalized patients.

Sponsorship: TINE BA, Oslo, Norway.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / adverse effects*
  • Bifidobacterium / growth & development*
  • Bifidobacterium / isolation & purification
  • Colony Count, Microbial
  • Cultured Milk Products
  • Diarrhea / chemically induced
  • Diarrhea / epidemiology
  • Diarrhea / prevention & control*
  • Double-Blind Method
  • Feces / microbiology
  • Female
  • Humans
  • Lacticaseibacillus rhamnosus / growth & development*
  • Lacticaseibacillus rhamnosus / isolation & purification
  • Lactobacillus acidophilus / growth & development*
  • Lactobacillus acidophilus / isolation & purification
  • Male
  • Middle Aged
  • Norway
  • Probiotics*
  • Risk Factors


  • Anti-Bacterial Agents