HIV-1 subtype D infection is associated with faster disease progression than subtype A in spite of similar plasma HIV-1 loads

J Infect Dis. 2007 Apr 15;195(8):1177-80. doi: 10.1086/512682. Epub 2007 Mar 2.


We investigated the effect of human immunodeficiency virus type 1 (HIV-1) subtype on disease progression among 145 Kenyan women followed from the time of HIV-1 acquisition. Compared with those infected with subtype A, women infected with subtype D had higher mortality (hazard ratio, 2.3 [95% confidence interval, 1.0-5.6]) and a faster rate of CD4 cell count decline (P=.003). The mortality risk persisted after adjustment for plasma HIV-1 load. There were no differences in plasma viral load by HIV-1 subtype during follow-up. HIV-1 subtype D infection is associated with a >2-fold higher risk of death than subtype A infection, in spite of similar plasma HIV-1 loads.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • CD4 Lymphocyte Count
  • DNA, Viral / blood
  • Disease Progression
  • Female
  • HIV Antibodies / blood
  • HIV Infections / mortality*
  • HIV Infections / physiopathology
  • HIV Infections / virology*
  • HIV-1 / classification*
  • HIV-1 / genetics
  • HIV-1 / immunology
  • HIV-1 / pathogenicity*
  • Humans
  • Kaplan-Meier Estimate
  • Kenya
  • Risk Factors
  • Time Factors
  • Viral Load*


  • DNA, Viral
  • HIV Antibodies