Major childhood infectious diseases and other determinants associated with type 1 diabetes: a case-control study

Acta Diabetol. 2007 Mar;44(1):14-9. doi: 10.1007/s00592-007-0235-9.


The objective of the study was to evaluate the association between infectious diseases and other events pertaining to childhood medical history and type 1 diabetes. A case-control study was carried out, taking as cases 159 type 1 diabetic patients (0-29 years) recorded from 1988 to 2000 within the population registry of the Pavia province (North Italy). As controls 318 non-diabetic subjects were matched by age and sex. A questionnaire was administered by standardised interviewers. Data were analysed by conditional logistic regression. Viral childhood diseases (OR 4.29; 95%CI 1.57-11.74) and bottle feeding (OR 1.83; 95%CI 1.08-3.09) were directly correlated to type 1 diabetes; an inverse correlation was found for vitamin D administration during lactation (0-14 years) (OR 0.31; 95%CI 0.11-0.86) and for history of scarlet fever in both sexes and age groups (OR 0.19; 95%CI 0.08-0.46). Most associations of the studied variables confirm already known findings. The significant inverse correlation of type 1 diabetes with scarlet fever history is a peculiar finding, the meaning of which is still obscure, although it has been recently described that streptococcal A infections are regulated by HLA class II alleles.

MeSH terms

  • Adolescent
  • Adult
  • Age of Onset
  • Breast Feeding
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Communicable Diseases / complications*
  • Communicable Diseases / epidemiology
  • Diabetes Mellitus, Type 1 / complications*
  • Diabetes Mellitus, Type 1 / epidemiology
  • Diabetes Mellitus, Type 1 / etiology
  • Family Health
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Risk Factors
  • Vitamin D / administration & dosage


  • Vitamin D