Hysteresis and bistability in a realistic cell model for calcium oscillations and action potential firing

Phys Rev Lett. 2007 Mar 2;98(9):098107. doi: 10.1103/PhysRevLett.98.098107. Epub 2007 Mar 1.

Abstract

Many cells reveal oscillatory behavior. Some cells reveal action-potential firing resulting from Hodgkin-Huxley (HH) type dynamics of ion channels in the cell membrane. Another type of oscillation relates to periodic inositol triphospate (IP3)-mediated calcium transients in the cytosol. In this study we present a bifurcation analysis of a cell with an excitable membrane and an IP3-mediated intracellular calcium oscillator. With IP3 concentration as a control parameter the model reveals a complex, rich spectrum of both stable and unstable solutions with hysteresis corresponding to experimental data. Our results reveal the emergence of complex behavior due to interactions between subcomponents with a relatively simple dynamical behavior.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / physiology*
  • Animals
  • Calcium / metabolism*
  • Calcium Channels / physiology*
  • Calcium Signaling / physiology*
  • Cell Line
  • Cell Membrane / physiology*
  • Computer Simulation
  • Inositol 1,4,5-Trisphosphate / metabolism
  • Ion Channel Gating / physiology
  • Kidney Tubules, Proximal / metabolism
  • Membrane Potentials / physiology
  • Models, Biological*
  • Rats

Substances

  • Calcium Channels
  • Inositol 1,4,5-Trisphosphate
  • Calcium