Effect of glycine on the immune response of the experimentally diabetic rats

Rev Alerg Mex. 2006 Nov-Dec;53(6):212-6.


Background: Hyperglycemia induces protein glycation, disturbing its function, additionally, the glycated products (AGEs) induce by themselves proinflammatory cytokine release that are responsible for insulin resistance. Glycine has been successfully used in diabetic patients to competitively reduce hemoglobin glycation.

Objectives: To assess hyperglycemia impact on the immune response and to evaluate if it is possible to reverse it by means of glycine administration.

Material and methods: Streptozotocin-induced diabetic rats, with and without glycine administration were challenged with sheep red blood cells, and specific antibody producing cells were accounted. Normal rats were challenged as controls.

Results: Induced diabetes modifies significantly the humoral immune response capacity versus sheep red blood cells. Also, glycine administration prevents against this deleterious effect.

Conclusions: Glycine could be an important therapeutic resource among diabetics to avoid the characteristic immunodeficiencies of this disease.

MeSH terms

  • Animals
  • Antibody Formation / drug effects*
  • Antibody-Producing Cells / drug effects
  • Antibody-Producing Cells / immunology
  • Blood Glucose / analysis
  • Diabetes Mellitus, Experimental / complications
  • Diabetes Mellitus, Experimental / immunology*
  • Drug Evaluation, Preclinical
  • Erythrocytes / immunology
  • Glycated Hemoglobin / analysis
  • Glycation End Products, Advanced / analysis
  • Glycine / pharmacology
  • Glycine / therapeutic use*
  • Immunologic Deficiency Syndromes / drug therapy*
  • Immunologic Deficiency Syndromes / etiology
  • Male
  • Rats
  • Rats, Wistar
  • Sheep
  • Streptozocin


  • Blood Glucose
  • Glycated Hemoglobin A
  • Glycation End Products, Advanced
  • Streptozocin
  • Glycine