Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human

Retrovirology. 2007 Mar 16;4:18. doi: 10.1186/1742-4690-4-18.

Abstract

In 1871, the observation of yellowish nodules in the enlarged spleen of a cow was considered to be the first reported case of bovine leukemia. The etiological agent of this lymphoproliferative disease, bovine leukemia virus (BLV), belongs to the deltaretrovirus genus which also includes the related human T-lymphotropic virus type 1 (HTLV-1). This review summarizes current knowledge of this viral system, which is important as a model for leukemogenesis. Recently, the BLV model has also cast light onto novel prospects for therapies of HTLV induced diseases, for which no satisfactory treatment exists so far.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anti-Retroviral Agents / pharmacology
  • Anti-Retroviral Agents / therapeutic use*
  • B-Lymphocytes / pathology
  • B-Lymphocytes / physiology
  • B-Lymphocytes / virology
  • Cattle
  • Cytokines / metabolism
  • Disease Models, Animal*
  • Enzootic Bovine Leukosis / drug therapy*
  • Enzootic Bovine Leukosis / physiopathology
  • Enzootic Bovine Leukosis / virology
  • Human T-lymphotropic virus 1 / pathogenicity
  • Humans
  • Leukemia Virus, Bovine / genetics
  • Leukemia Virus, Bovine / metabolism
  • Leukemia Virus, Bovine / pathogenicity*
  • Leukemia-Lymphoma, Adult T-Cell / drug therapy*
  • Leukemia-Lymphoma, Adult T-Cell / physiopathology
  • Leukocytes, Mononuclear / pathology
  • Leukocytes, Mononuclear / physiology
  • Leukocytes, Mononuclear / virology
  • Sheep
  • Sheep Diseases / drug therapy*
  • Sheep Diseases / immunology
  • Sheep Diseases / physiopathology
  • Sheep Diseases / virology
  • Viral Proteins / genetics
  • Viral Proteins / metabolism

Substances

  • Anti-Retroviral Agents
  • Cytokines
  • Viral Proteins