Regulation of UV-induced DNA damage response by ubiquitylation

DNA Repair (Amst). 2007 Sep 1;6(9):1231-42. doi: 10.1016/j.dnarep.2007.01.012. Epub 2007 Mar 23.

Abstract

Like many other cellular processes, regulation of the DNA damage response (DDR) is regulated at different levels, ranging from transcriptional control to an array of distinct post-translational modifications. Involvement of ubiquitylation and the ubiquitin proteasome system in adjusting DDR are such protein modifications that were receiving increasing attention in the field. In this review we summarize and discuss a few recent key publications addressing the issue of DDR factor ubiquitylation, focusing on UV-induced DDR. We discuss the implications of these modifications to allow swift adaptation and regulation of genome surveillance factors.

Publication types

  • Review

MeSH terms

  • DNA Damage / radiation effects*
  • DNA Repair / radiation effects
  • Humans
  • Proteasome Endopeptidase Complex
  • Protein Processing, Post-Translational
  • Ubiquitin / metabolism*
  • Ubiquitin-Protein Ligase Complexes / metabolism*
  • Ultraviolet Rays*

Substances

  • Ubiquitin
  • Ubiquitin-Protein Ligase Complexes
  • Proteasome Endopeptidase Complex