Adrenergic and cholinergic regulation of gastric mucus phospholipid secretion

Scand J Gastroenterol. 1992;27(1):29-32. doi: 10.3109/00365529209011162.


The influence of adrenergic and cholinergic agonists on phospholipid secretion in gastric mucosal cells maintained in the presence of [3H]choline was investigated. The secretion of [3H]choline phospholipids over a 30-min period averaged 1.98% of the total cellular labeled phospholipids in the absence of any mediator and was enhanced by the beta-adrenergic agonist isoproterenol to a greater extent than by the cholinergic agonist pilocarpine. A 2-fold increase in phospholipid secretion was achieved with isoproterenol, whereas pilocarpine produced a 1.3-fold increase. The stimulatory effect of isoproterenol was inhibited by alprenolol, and that of pilocarpine by atropine. The phospholipids secreted in response to isoproterenol showed a 30% decrease in lysophosphatidylcholine, whereas a 2.1-fold enrichment in this phospholipid occurred with pilocarpine. The results demonstrate the involvement of neural mediators in the regulation of phospholipid secretion in gastric mucus.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alprenolol / pharmacology
  • Animals
  • Atropine / pharmacology
  • Autonomic Agents / pharmacology*
  • Cells, Cultured
  • Gastric Mucosa / drug effects
  • Gastric Mucosa / metabolism*
  • Isoproterenol / pharmacology
  • Male
  • Phospholipids / metabolism*
  • Pilocarpine / pharmacology
  • Rats
  • Rats, Inbred Strains
  • Time Factors


  • Autonomic Agents
  • Phospholipids
  • Pilocarpine
  • Atropine
  • Alprenolol
  • Isoproterenol