The Son of sevenless gene product: a putative activator of Ras

Science. 1992 Jan 31;255(5044):603-6. doi: 10.1126/science.1736363.


The Son of sevenless (Sos) gene functions in signaling pathways initiated by the sevenless and epidermal growth factor receptor tyrosine kinases. The Sos gene has now been isolated and sequenced. Its product is a 1595-amino acid protein similar to the CDC25 protein in Saccharomyces cerevisiae, a guanine nucleotide exchange factor that activates Ras. These results imply a role for the ras pathway in Drosophila neuronal development.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cell Cycle Proteins*
  • Drosophila / genetics*
  • Fungal Proteins / genetics
  • Gene Library
  • Genes, ras*
  • Genotype
  • Membrane Proteins / genetics*
  • Molecular Sequence Data
  • Neurons / physiology
  • Restriction Mapping
  • Saccharomyces cerevisiae / genetics
  • Sequence Homology, Nucleic Acid
  • Son of Sevenless Proteins
  • ras-GRF1*


  • Cell Cycle Proteins
  • Fungal Proteins
  • Membrane Proteins
  • Son of Sevenless Proteins
  • ras-GRF1

Associated data

  • GENBANK/M83931