Urinary F2-isoprostanes are poor prognostic indicators for the development of bronchopulmonary dysplasia

J Perinatol. 2007 May;27(5):303-6. doi: 10.1038/sj.jp.7211684. Epub 2007 Mar 15.


Objective: Oxygen toxicity is thought to contribute to the development of bronchopulmonary dysplasia (BPD). Oxidant injury leads to formation of F(2)-isoprostanes (F(2)-IsoP). We hypothesized that urinary excretion of the stable metabolite of F(2)-IsoP, 8-iso-PGF(2alpha), would be higher in infants who develop BPD than those who did not.

Methods: Forty infants <30-weeks gestational age (GA) were enrolled, 24 infants with BPD and 16 without BPD. Urine specimens were collected weekly and stored at -80 degrees C until analyzed. Urinary 8-iso-PGF(2alpha) was measured by gas chromatography/mass spectrometry (GC-MS) and normalized to creatinine excretion.

Results: GA and birth weight (BW) were lower in infants who developed BPD than those who did not. Urinary 8-iso-PGF(2alpha) levels in the first or third weeks of age were not significantly different between the two groups.

Conclusion: Urinary excretion of 8-iso-PGF(2alpha) in early postnatal life in preterm infants is not correlated with the development of BPD.

MeSH terms

  • Biomarkers / blood
  • Biomarkers / urine*
  • Birth Weight
  • Bronchopulmonary Dysplasia / diagnosis*
  • Bronchopulmonary Dysplasia / urine
  • Dinoprost / analogs & derivatives
  • Dinoprost / blood
  • F2-Isoprostanes / urine*
  • Female
  • Gas Chromatography-Mass Spectrometry
  • Humans
  • Infant, Newborn
  • Infant, Very Low Birth Weight
  • Male
  • Predictive Value of Tests
  • Prognosis
  • Risk Factors


  • Biomarkers
  • F2-Isoprostanes
  • 8-epi-prostaglandin F2alpha
  • Dinoprost