Continuous renal replacement therapy is associated with less chronic renal failure than intermittent haemodialysis after acute renal failure

Intensive Care Med. 2007 May;33(5):773-780. doi: 10.1007/s00134-007-0590-6. Epub 2007 Mar 16.


Objective: Acute renal failure can be treated with continuous renal replacement therapy (CRRT) or intermittent haemodialysis (IHD). Whether this choice affects renal recovery has been debated, since it has implications on quality of life and costs. Our objective was to determine the impact of CRRT and IHD on renal recovery.

Design: Nationwide retrospective cohort study between the years 1995 and 2004. Follow-up ranged between 3 months and 10 years.

Setting: Thirty-two Swedish intensive care units.

Patients and participants: Eligible subjects were adults treated in Swedish general intensive care units with RRT. A total of 2,642 patients from 32 ICUs were included. We then excluded patients with end-stage renal disease (252) and patients lacking a diagnosis in the in-patient register (188). Thus, 2,202 patients were studied. Follow-up was complete.

Interventions: None.

Measurements and results: The primary outcome was renal recovery. Secondarily we studied the mortality of the cohort. There were no differences between IHD and CRRT patients regarding baseline characteristics, such as age, sex and comorbidities. Of the 1,102 patients surviving 90 days after inclusion in the cohort, 944 (85.7%) were treated with CRRT and 158 (14.3%) were treated with IHD. Seventy-eight patients (8.3%; confidence interval, CI, 6.6-10.2), never recovered their renal function in the CRRT group. The proportion was significantly higher among IHD patients, where 26 subjects or 16.5% (CI 11.0-23.2) developed need for chronic dialysis.

Conclusions: The use of CRRT is associated with better renal recovery than IHD, but mortality does not differ between the groups.

MeSH terms

  • Acute Kidney Injury / mortality
  • Acute Kidney Injury / therapy*
  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Follow-Up Studies
  • Humans
  • Intensive Care Units
  • Kidney Failure, Chronic / mortality
  • Kidney Failure, Chronic / therapy*
  • Male
  • Middle Aged
  • Multicenter Studies as Topic
  • Registries
  • Renal Dialysis / methods*
  • Renal Replacement Therapy / methods*
  • Retrospective Studies
  • Survival Rate
  • Sweden