Host innate immune response to Mycobacterium tuberculosis

J Clin Immunol. 2007 Jul;27(4):347-62. doi: 10.1007/s10875-007-9084-0. Epub 2007 Mar 16.


This review focuses on recent progress in our understanding of Mycobacterium tuberculosis survival in macrophages, the interaction of M. tuberculosis with Toll-like receptors (TLRs) and the establishment of the link between innate and adaptive immunity, and TLRs and interferon-gamma-mediated antimicrobial pathways in macrophages. We also propose a paradigm that TLR2 signaling regulates the magnitude of the host Th1 response leading to either M. tuberculosis persistence and latent infection or replication and disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Host-Pathogen Interactions*
  • Humans
  • Immunity, Active
  • Immunity, Innate*
  • Macrophages / immunology*
  • Mycobacterium tuberculosis / immunology*
  • Toll-Like Receptors / physiology


  • Toll-Like Receptors