Juvenile nasopharyngeal angiofibromas in Denmark 1981-2003: diagnosis, incidence, and treatment

Acta Otolaryngol. 2007 Mar;127(3):292-9. doi: 10.1080/00016480600818138.


Conclusions: Juvenile nasopharyngeal angiofibroma (JNA) is a rare tumor in young males, with a non-negligible potential for recurrence. Preoperative embolization is a safe procedure that diminishes the peroperative blood loss and the need for blood transfusion. The endoscopic approach was used with good results in JNA stage I and II (Chandler).

Objectives: To estimate the incidence rate of JNA in the Danish population and to describe symptoms and treatment.

Patients and methods: This was a national retrospective cohort study. All cases of JNA diagnosed in Denmark from 1981 to 2003 were identified. Data were extracted from medical records.

Results: Forty-five male (no female) JNA cases were identified. In 43 cases, clinical data were recovered. Median age was 15 years. The incidence rate in Denmark was 0.4 cases per million inhabitants per year and 3.7 cases per million males (aged 10-24) per year. All patients underwent surgery, and the endoscopic approach was increasingly being used. The embolization procedure proved to be safe and decreased the intraoperative blood loss statistically to 650 ml in the embolized group from an average of 1200 ml in the non-embolized group (p<0.05). Similarly, the need for peroperative blood transfusion was reduced (p<0.005). The primary recurrence rate was 23% and no patients died.

MeSH terms

  • Adolescent
  • Adult
  • Angiofibroma / diagnosis*
  • Angiofibroma / epidemiology
  • Angiofibroma / pathology
  • Angiofibroma / surgery
  • Blood Loss, Surgical / prevention & control
  • Child
  • Cohort Studies
  • Combined Modality Therapy
  • Cross-Sectional Studies
  • Denmark / epidemiology
  • Embolization, Therapeutic
  • Endoscopy
  • Humans
  • Incidence
  • Male
  • Nasopharyngeal Neoplasms / diagnosis*
  • Nasopharyngeal Neoplasms / epidemiology
  • Nasopharyngeal Neoplasms / pathology
  • Nasopharyngeal Neoplasms / surgery
  • Neoadjuvant Therapy
  • Neoplasm Staging
  • Retrospective Studies