Scedosporium Prolificans Brain Abscess in a Patient With Chronic Granulomatous Disease: Successful Combination Therapy With Voriconazole and Terbinafine

Scand J Infect Dis. 2007;39(1):87-90. doi: 10.1080/00365540600786564.

Abstract

A patient with chronic granulomatous disease developed brain abscesses with Scedosporium prolificans. In vitro susceptibility revealed a synergistic effect of terbinafine and voriconazole. He received therapy with both these antifungals which resulted in disappearance of the brain abscesses. This is the first reported cure of a CNS S. prolificans infection in an immunocompromised host.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antifungal Agents / therapeutic use*
  • Brain Abscess / drug therapy*
  • Brain Abscess / microbiology
  • Central Nervous System Fungal Infections / drug therapy*
  • Drug Resistance, Fungal / drug effects
  • Granulomatous Disease, Chronic / complications
  • Granulomatous Disease, Chronic / microbiology
  • Humans
  • Male
  • Naphthalenes / therapeutic use*
  • Pyrimidines / therapeutic use*
  • Scedosporium / drug effects*
  • Scedosporium / pathogenicity
  • Terbinafine
  • Triazoles / therapeutic use*
  • Voriconazole

Substances

  • Antifungal Agents
  • Naphthalenes
  • Pyrimidines
  • Triazoles
  • Terbinafine
  • Voriconazole