Mild influenza encephalopathy with biphasic seizures and late reduced diffusion

J Neurol Sci. 2007 May 15;256(1-2):86-9. doi: 10.1016/j.jns.2007.02.006. Epub 2007 Mar 23.


Two Japanese infants with influenza A infection presented with a brief febrile seizure, followed by secondary seizures and disturbance of consciousness on day 5. Magnetic resonance imaging revealed reduced subcortical diffusion around day 5. Both were diagnosed with mild form of acute encephalopathy syndrome characterized by biphasic seizures and late reduced diffusion. It is important for clinicians in Asian countries to recognize and to inform parents that secondary progression may occur even after a brief febrile seizure with influenza.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cerebral Cortex / pathology
  • Diffusion Magnetic Resonance Imaging*
  • Electroencephalography / methods
  • Encephalitis, Viral / complications*
  • Humans
  • Infant
  • Influenza, Human / complications*
  • Male
  • Seizures / etiology*
  • Seizures / pathology*