Weaning from mechanical ventilation

Crit Care Clin. 2007 Apr;23(2):263-74, x. doi: 10.1016/j.ccc.2006.12.002.


Approximately 20% of all mechanically ventilated patients fail their first attempt to wean. Prolonged mechanical ventilation increases morbidity, mortality, and costs. No single weaning parameter predicts patient ability to wean. Weaning studies suggest that daily trials of spontaneous breathing for appropriate patients assured by standing protocol and driven by respiratory care practitioners and/or nurses improve the weaning process and patient outcome.

MeSH terms

  • Critical Care / methods*
  • Humans
  • Pulmonary Disease, Chronic Obstructive / therapy
  • Respiration, Artificial / adverse effects
  • Respiration, Artificial / methods*
  • Respiratory Insufficiency / etiology
  • Respiratory Insufficiency / physiopathology
  • Ventilator Weaning / adverse effects
  • Ventilator Weaning / methods*