Maternal serum corticotropin-releasing hormone and ACTH levels as predictive markers of premature labor

Int J Gynaecol Obstet. 2007 May;97(2):115-9. doi: 10.1016/j.ijgo.2007.01.007. Epub 2007 Mar 21.


Objective: To investigate whether corticotropin-releasing hormone (CRH) and corticotropin (ACTH) plasma concentrations in women diagnosed with preterm labor are of potential clinical value in the assessment of the risk of preterm birth.

Method: Plasma samples of 79 women diagnosed with preterm labor were used in this study. Samples were divided into three groups based on the week of gestation (24th-28th, 29th-32nd, 33rd-37th). CRH and ACTH values were determined by ELISA.

Result: Mean maternal peripheral plasma values of CRH and ACTH were significantly higher (p<0.001) in women who were initially diagnosed with preterm labor and finally delivered a preterm birth, compared to women with the same diagnosis but with term birth.

Conclusion: CRH and ACTH serum levels in women diagnosed with preterm labor could be used as predictors for the timing of parturition.

Publication types

  • Evaluation Study

MeSH terms

  • Adrenocorticotropic Hormone / blood*
  • Adult
  • Biomarkers
  • Corticotropin-Releasing Hormone / blood*
  • Female
  • Gestational Age
  • Humans
  • Obstetric Labor, Premature / blood*
  • Obstetric Labor, Premature / physiopathology
  • Predictive Value of Tests
  • Pregnancy
  • Premature Birth / diagnosis*


  • Biomarkers
  • Adrenocorticotropic Hormone
  • Corticotropin-Releasing Hormone