Intracellular trafficking of TRP channels

Cell Calcium. 2007 Aug;42(2):225-32. doi: 10.1016/j.ceca.2007.01.014. Epub 2007 Mar 21.


Thirteen years ago, it was suggested that exocytotic insertion of store-operated channels into the plasma membrane lead to increased Ca(2+) entry in non-excitable cells upon G protein-coupled or tyrosine kinase receptor stimulation. Since the discovery of the TRP channel superfamily and their involvement in receptor-induced Ca(2+) entry, many studies have shown that different members of the TRP superfamily translocate into the plasma membrane upon stimulation. While the exact molecular mechanism by which TRP channels insert into the plasma membrane is unknown, TRP-binding proteins have been shown to directly regulate this trafficking. This review summarizes recent advances related to the mechanism of TRP channel trafficking, focusing on the role of TRP-binding proteins.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Calcium Channels / metabolism*
  • Carrier Proteins / metabolism
  • Hormones / pharmacology
  • Protein Transport / drug effects
  • Protein Transport / radiation effects
  • SNARE Proteins / metabolism
  • TRPC Cation Channels / metabolism*
  • rab GTP-Binding Proteins / metabolism


  • Calcium Channels
  • Carrier Proteins
  • Hormones
  • SNARE Proteins
  • TRPC Cation Channels
  • rab GTP-Binding Proteins