Studies of long-term noopept and afobazol treatment in rats with learned helplessness neurosis

Bull Exp Biol Med. 2006 Aug;142(2):202-4. doi: 10.1007/s10517-006-0327-5.
[Article in English, Russian]


Long-lasting effects of new Russian psychotropic drugs Noopept and Afobazol on active avoidance conditioning and formation of learned helplessness neurosis were studied on an original experimental model in rats. Noopept eliminated the manifestations of learned helplessness after long-term (21-day) treatment by increasing the percent of trained animals. Afobazol was low effective in preventing manifestations of learned helplessness, but if used for a long time, it reduced the incidence of learned helplessness development by increasing the percent of untrained animals.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Avoidance Learning / drug effects*
  • Benzimidazoles / pharmacology
  • Benzimidazoles / therapeutic use*
  • Depressive Disorder / drug therapy*
  • Dipeptides / pharmacology
  • Dipeptides / therapeutic use*
  • Exploratory Behavior / drug effects
  • Helplessness, Learned*
  • Male
  • Morpholines / pharmacology
  • Morpholines / therapeutic use*
  • Psychotropic Drugs / pharmacology
  • Psychotropic Drugs / therapeutic use*
  • Rats


  • 2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole
  • Benzimidazoles
  • Dipeptides
  • Morpholines
  • Psychotropic Drugs
  • ethyl phenylacetyl-Pro-Gly