Hepatoprotective and antioxidant activity of meadowsweet extract during experimental toxic hepatitis

I V Shilova; T V Zhavoronok; N I Suslov; E A Krasnov; T P Novozheeva; A V Veremeev; M G Nagaev; G V Petina

doi:10.1007/s10517-006-0331-9

Hepatoprotective and antioxidant activity of meadowsweet extract during experimental toxic hepatitis

Bull Exp Biol Med. 2006 Aug;142(2):216-8. doi: 10.1007/s10517-006-0331-9.

[Article in English, Russian]

Authors

I V Shilova¹, T V Zhavoronok, N I Suslov, E A Krasnov, T P Novozheeva, A V Veremeev, M G Nagaev, G V Petina

Affiliation

¹ Department of Biochemistry and Spectral Analysis, Central Research Laboratory, Siberian State Medical University, Tomsk. licvostok@mail.tomsknet.ru

PMID: 17369943
DOI: 10.1007/s10517-006-0331-9

Abstract

The extract of meadowsweet aerial parts exhibits hepatoprotective and antioxidant activity during experimental toxic CCl(4) hepatitis. This extract improved liver function. Meadowsweet extract in 70% ethanol (100 mg/kg) was most potent and exhibited low toxicity. By several parameters the effectiveness of this extract surpassed that of Carsil.

Publication types

Comparative Study

MeSH terms

Animals
Antioxidants / pharmacology
Antioxidants / therapeutic use*
Carbon Tetrachloride / toxicity
Chemical and Drug Induced Liver Injury / drug therapy*
Filipendula / chemistry*
Liver / drug effects*
Liver / physiopathology
Male
Phytotherapy / methods*
Plant Extracts / pharmacology
Plant Extracts / therapeutic use*
Rats

Substances

Antioxidants
Plant Extracts
Carbon Tetrachloride