Indices of platelet activation and the stability of coronary artery disease

J Thromb Haemost. 2007 Apr;5(4):761-5. doi: 10.1111/j.1538-7836.2007.02462.x. Epub 2007 Feb 26.


Aim: To determine whether indices of platelet activation are associated with the stability of coronary artery disease (CAD).

Methods: Platelet function was examined in 677 consecutive aspirin-treated patients presenting for cardiac catheterization. Patients were grouped into recent myocardial infarction (MI), no MI but angiographically documented CAD (non-MI CAD) and no angiographically detectible CAD (no CAD), as well as additional subgroups.

Results: Compared with non-MI CAD or no CAD patients, more patients with recent MI had a shortened platelet function analyzer (PFA)-100 collagen-epinephrine closure time (CT) and increased circulating monocyte-platelet aggregates, neutrophil-platelet aggregates, activated platelet surface GPIIb-IIIa and plasma soluble CD40 ligand (sCD40L). More patients with non-MI CAD had shortened PFA-100 CTs and increased monocyte-platelet aggregates compared with patients with no CAD. Platelet surface P-selectin did not differ among the groups. Subgroup analysis revealed that decreasing PFA-100 CT correlated with the stability of CAD.

Conclusions: Indices of platelet activation, especially the PFA-100 CT, are associated with the stability of CAD, and may reflect plaque instability, an ongoing thrombotic state and/or reduced responsiveness to aspirin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Aspirin / pharmacology
  • CD40 Ligand / metabolism
  • Coronary Artery Disease / blood*
  • Coronary Artery Disease / diagnosis
  • Coronary Artery Disease / therapy*
  • Epinephrine / metabolism
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neutrophils / metabolism
  • P-Selectin / biosynthesis
  • Platelet Activation*
  • Platelet Function Tests
  • Platelet Glycoprotein GPIIb-IIIa Complex / metabolism


  • Anti-Inflammatory Agents, Non-Steroidal
  • P-Selectin
  • Platelet Glycoprotein GPIIb-IIIa Complex
  • CD40 Ligand
  • Aspirin
  • Epinephrine