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. 2007 May;49(5):1063-9.
doi: 10.1161/HYPERTENSIONAHA.107.087288. Epub 2007 Mar 19.

Plasma 25-hydroxyvitamin D Levels and Risk of Incident Hypertension


Plasma 25-hydroxyvitamin D Levels and Risk of Incident Hypertension

John P Forman et al. Hypertension. .


Hydroxylation of 25(OH)D to 1,25-dihydroxyvitamin D and signaling through the vitamin D receptor occur in various tissues not traditionally involved in calcium homeostasis. Laboratory studies indicate that 1,25-dihydroxyvitamin D suppresses renin expression and vascular smooth muscle cell proliferation; clinical studies demonstrate an inverse association between ultraviolet radiation, a surrogate marker for vitamin D synthesis, and blood pressure. We prospectively studied the independent association between measured plasma 25-hydroxyvitamin D [25(OH)D] levels and risk of incident hypertension and also the association between predicted plasma 25(OH)D levels and risk of incident hypertension. Two prospective cohort studies including 613 men from the Health Professionals' Follow-Up Study and 1198 women from the Nurses' Health Study with measured 25(OH)D levels were followed for 4 to 8 years. In addition, 2 prospective cohort studies including 38 388 men and 77 531 women with predicted 25(OH)D levels were followed for 16 to 18 years. During 4 years of follow-up, the multivariable relative risk of incident hypertension among men whose measured plasma 25(OH)D levels were <15 ng/mL (ie, vitamin D deficiency) compared with those whose levels were >or=30 ng/mL was 6.13 (95% confidence interval [CI]: 1.00 to 37.8). Among women, the same comparison yielded a relative risk of 2.67 (95% CI: 1.05 to 6.79). The pooled relative risk combining men and women with measured 25(OH)D levels using the random-effects model was 3.18 (95% CI: 1.39 to 7.29). Using predicted 25(OH)D levels in the larger cohorts, the multivariable relative risks comparing the lowest to highest deciles were 2.31 (95% CI: 2.03 to 2.63) in men and 1.57 (95% CI: 1.44 to 1.72) in women. Plasma 25(OH)D levels are inversely associated with risk of incident hypertension.

Comment in

  • Vitamin D levels and the risk of hypertension.
    Atlas SA, Patel SS. Atlas SA, et al. Curr Hypertens Rep. 2007 Dec;9(6):447-9. doi: 10.1007/s11906-007-0082-7. Curr Hypertens Rep. 2007. PMID: 18367006 No abstract available.
  • Vitamin D and hypertension.
    Hermann M, Ruschitzka F. Hermann M, et al. Curr Hypertens Rep. 2008 Feb;10(1):49-51. doi: 10.1007/s11906-008-0010-5. Curr Hypertens Rep. 2008. PMID: 18367026 No abstract available.

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