Esthesioneuroblastoma: a population-based analysis of survival and prognostic factors

Arch Otolaryngol Head Neck Surg. 2007 Mar;133(3):276-80. doi: 10.1001/archotol.133.3.276.


Objectives: To investigate the characteristics associated with survival in esthesioneuroblastoma and to determine whether the modified Kadish staging system can predict outcome.

Design: Retrospective population-based cohort study.

Subjects: All patients in the Surveillance, Epidemiology, and End Results tumor registry diagnosed as having esthesioneuroblastoma (1973-2002).

Main outcome measures: The modified Kadish stage and the overall and disease-specific survival rates were determined.

Results: The cohort included 311 patients with a mean age of 53 years and a unimodal age distribution. The overall 5- and 10-year survival rates were 62.1% and 45.6%, respectively. The modified Kadish staging system was applied to 261 patients. Kaplan-Meier analysis showed the overall and disease-specific survival rates at 10 years to be 83.4% and 90%, respectively, for patients with stage A disease; 49% and 68.3% for patients with stage B disease; 38.6% and 66.7% for patients with stage C disease; and 13.3% and 35.6% for patients with stage D disease. Log-rank test comparisons found Kadish stage (P<.01), treatment modality (P<.002), lymph node status (P<.01), and age at diagnosis (P<.001) to be significant predictors of survival. Cox regression analysis confirmed that Kadish stage remained a significant predictor of disease-specific survival.

Conclusion: The modified Kadish staging system, lymph node status, treatment modality, and age are useful predictors of survival in patients who present with esthesioneuroblastoma.

Publication types

  • Evaluation Study

MeSH terms

  • Adolescent
  • Adult
  • Age Distribution
  • Aged
  • Aged, 80 and over
  • Child
  • Child, Preschool
  • Cohort Studies
  • Esthesioneuroblastoma, Olfactory / mortality*
  • Esthesioneuroblastoma, Olfactory / pathology
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Kaplan-Meier Estimate
  • Lymph Nodes / pathology*
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Nasal Cavity*
  • Neoplasm Staging / methods*
  • Nose Neoplasms / mortality*
  • Nose Neoplasms / pathology
  • Prognosis
  • Proportional Hazards Models
  • Retrospective Studies
  • SEER Program
  • Survival Rate