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Comparative Study
, 22 (4), 527-30

Primary Care Office-Based Buprenorphine Treatment: Comparison of Heroin and Prescription Opioid Dependent Patients

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Comparative Study

Primary Care Office-Based Buprenorphine Treatment: Comparison of Heroin and Prescription Opioid Dependent Patients

Brent A Moore et al. J Gen Intern Med.

Abstract

Background: Prescription opioid dependence is increasing, but treatment outcomes with office-based buprenorphine/naloxone among these patients have not been described.

Methods: We compared demographic, clinical characteristics and treatment outcomes among 200 patients evaluated for entry into a trial of primary care office-based buprenorphine/naloxone treatment stratifying on those who reported exclusive heroin use (n = 124), heroin and prescription opioid use (n = 47), or only prescription opioid use (n = 29).

Results: Compared to heroin-only patients, prescription-opioid-only patients were younger, had fewer years of opioid use, and less drug treatment history. They were also more likely to be white, earned more income, and were less likely to have Hepatitis C antibodies. Prescription-opioid-only patients were more likely to complete treatment (59% vs. 30%), remained in treatment longer (21.0 vs. 14.2 weeks), and had a higher percent of opioid-negative urine samples than heroin only patients (56.3% vs. 39.8%), all p values < .05. Patients who used both heroin and prescription opioids had outcomes that were intermediate between heroin-only and prescription-opioid-only patients.

Conclusions: Individuals dependent on prescription opioids have an improved treatment response to buprenorphine/naloxone maintenance in an office-based setting compared to those who exclusively or episodically use heroin.

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References

    1. None
    2. Office of Applied Studies. Results from the 2003 National Survey on Drug Use and Health: National findings (DHHS Publication No. SMA 04-3964, NHSDA Series H-25). Rockville, MD: Substance Abuse and Mental Health Services Administration; 2004.
    1. {'text': '', 'index': 1, 'ids': [{'type': 'DOI', 'value': '10.1016/j.drugalcdep.2004.05.001', 'is_inner': False, 'url': 'https://doi.org/10.1016/j.drugalcdep.2004.05.001'}, {'type': 'PubMed', 'value': '15488345', 'is_inner': True, 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/15488345/'}]}
    2. Potter JS, Hennessy G, Borrow JA, Greenfield SF, Weiss RD. Substance use histories in patients seeking treatment for controlled-release oxycodone dependence. Drug Alcohol Depend. 2004;76:213–15. - PubMed
    1. {'text': '', 'index': 1, 'ids': [{'type': 'PMC', 'value': 'PMC1448242', 'is_inner': False, 'url': 'http://www.ncbi.nlm.nih.gov/pmc/articles/pmc1448242/'}, {'type': 'PubMed', 'value': '14759941', 'is_inner': True, 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/14759941/'}]}
    2. Simoni-Wastila L, Strickler G. Risk factors associated with problem use of prescription drugs. Am J Public Health. 2004;94:266–8. - PMC - PubMed
    1. {'text': '', 'index': 1, 'ids': [{'type': 'DOI', 'value': '10.1081/JA-120027764', 'is_inner': False, 'url': 'https://doi.org/10.1081/ja-120027764'}, {'type': 'PubMed', 'value': '15002942', 'is_inner': True, 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/15002942/'}]}
    2. Simoni-Wastila L, Ritter G, Strickler G. Gender and other factors associated with the nonmedical use of abusable prescription drugs. Subst Use Misuse. 2004;39:1–23. - PubMed
    1. {'text': '', 'index': 1, 'ids': [{'type': 'DOI', 'value': '10.1081/ADA-120002972', 'is_inner': False, 'url': 'https://doi.org/10.1081/ada-120002972'}, {'type': 'PubMed', 'value': '12014814', 'is_inner': True, 'url': 'http://www.ncbi.nlm.nih.gov/pubmed/12014814/'}]}
    2. Fiellin DA, Pantalon MV, Pakes J, O’Connor PG, Chawarski M, Schottenfeld RS. Treatment of heroin dependence with buprenorphine in primary care. Am J Drug Alcohol Abuse. 2002;28:231–41. - PubMed

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