Urticarial vasculitis secondary to paroxetine

J Drugs Dermatol. 2006 Nov-Dec;5(10):1012-4.


Paroxetine (Paxil) is a widely prescribed antidepressant of the selective serotonin reuptake inhibitor (SSRI) class for which multiple cutaneous adverse effects have been reported, including urticaria, ecchymoses, vasculitis, and pruritus. In contrast, fluoxetine (Prozac) is the only SSRI previously reported to cause urticarial vasculitis. Urticarial vasculitis is a chronic disorder marked by recurrent episodes of erythematous, indurated wheals that histologically manifest the features of leukocytoclastic vasculitis. This case represents the first reported incidence of paroxetine-induced urticarial vasculitis, and highlights the need to consider the entire SSRI class as s as a potential cause of the condition.

Publication types

  • Case Reports

MeSH terms

  • Depressive Disorder / drug therapy
  • Humans
  • Middle Aged
  • Paroxetine / adverse effects*
  • Paroxetine / therapeutic use
  • Selective Serotonin Reuptake Inhibitors / adverse effects
  • Selective Serotonin Reuptake Inhibitors / therapeutic use
  • Skin / blood supply
  • Skin / drug effects
  • Skin / pathology
  • Urticaria / chemically induced*
  • Vasculitis / chemically induced*
  • Vasculitis / diagnosis


  • Serotonin Uptake Inhibitors
  • Paroxetine